Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 7/20 | 0.47 |
| ▸ | BCL2 | P10415 | 6/20 | 0.47 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27517284 | 0.80 | MEN1 (0.37) | ALDH1A1TDP1SMN1; SMN2LCKMEN1 | |
| SCHEMBL27516293 | 0.78 | KDM4E (0.38) | ALDH1A1TDP1NPC1CYP3A4TSHR | |
| SCHEMBL27515970 | 0.75 | PTK2 (0.36) | MAPK1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL27528054 | 0.75 | CA3 (0.33) | ALDH1A1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL5594898 | 0.75 | PARP1 (0.39) | ALDH1A1MAPK1TDP1CYP3A4TSHR | |
| SCHEMBL27499547 | 0.75 | MAOB (0.34) | ALDH1A1NPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL27499553 | 0.74 | ACMSD (0.43) | MCL1ALDH1A1MAPK1MEN1MAPT | |
| SCHEMBL5612906 | 0.74 | TTR (0.40) | TTRALDH1A1TDP1PTPRCMAPT | |
| SCHEMBL27515567 | 0.74 | CXCR1 (0.35) | MCL1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL7185410 | 0.72 | MEN1 (0.38) | ALDH1A1SMN1; SMN2MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809492-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2007-01-24 | — | — | EP | disclosed |
| CN-1539816-A | IL-8 receptor antagonists | ʷ��˿�������ȳ�ķ����˾ | 2004-10-27 | — | — | CN | disclosed |
| CN-1355697-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | CN | disclosed |
| CN-1215990-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1999-05-05 | — | — | CN | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |