Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27605669 | 0.85 | CA12 (0.47) | LCKMAPTTSHRHSD17B10POLB | |
| SCHEMBL27515596 | 0.85 | CES1 (0.37) | PARP10 | |
| SCHEMBL27535699 | 0.83 | PLAU (0.47) | PTPN1MAPTPLAUMAPK1SMN1; SMN2 | |
| SCHEMBL27516293 | 0.83 | KDM4E (0.38) | MAPTTSHRHSD17B10POLBCYP3A4 | |
| SCHEMBL27528054 | 0.83 | CA3 (0.33) | PARP1MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL27515970 | 0.83 | PTK2 (0.36) | MAPTMAPK1SMN1; SMN2LMNAHTT | |
| SCHEMBL27576101 | 0.83 | EGFR (0.41) | HSD17B10CA2KDM4ELMNA | |
| SCHEMBL27499553 | 0.82 | ACMSD (0.43) | MAPTHSD17B10MAPK1KDM4EALDH1A1 | |
| SCHEMBL6823428 | 0.81 | KMT2A (0.38) | MAPTPOLBRECQLTDP1CA2 | |
| SCHEMBL27499849 | 0.81 | ALDH1A1 (0.52) | HSD17B10L3MBTL1CA2PLAUSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809492-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2007-01-24 | — | — | EP | disclosed |
| CN-1539816-A | IL-8 receptor antagonists | ʷ��˿�������ȳ�ķ����˾ | 2004-10-27 | — | — | CN | disclosed |
| CN-1355697-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 2002-06-26 | — | — | CN | disclosed |
| CN-1215990-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1999-05-05 | — | — | CN | disclosed |
| EP-0809492-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025157-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-08-22 | — | — | WO | disclosed |