Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | CES2 | O00748 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4263577 | 0.85 | CYP1A2 (0.42) | CYP1A2CYP2A6HIF1AEPAS1MAPT | |
| SCHEMBL13995087 | 0.81 | BRD4 (0.32) | — | |
| SCHEMBL260441 | 0.80 | CYP1A2 (0.68) | CYP1A2CYP2A6HIF1AEPAS1MAPT | |
| SCHEMBL29416731 | 0.80 | CYP1A2 (0.68) | CYP1A2CYP2A6HIF1AEPAS1MAPT | |
| SCHEMBL2380918 | 0.80 | CYP1A2 (0.68) | CYP1A2CYP2A6HIF1AEPAS1MAPT | |
| SCHEMBL4264605 | 0.79 | SMN1; SMN2 (0.49) | CYP1A2HIF1AEPAS1MAPTTDP1 | |
| SCHEMBL13861752 | 0.75 | CD274 (0.35) | HIF1AEPAS1MAPTTDP1CES2 | |
| SCHEMBL22345737 | 0.75 | CA12 (0.41) | CYP1A2CYP2A6MCL1ALDH1A1HPGD | |
| SCHEMBL22345783 | 0.75 | CA12 (0.41) | CYP1A2CYP2A6MCL1ALDH1A1HPGD | |
| SCHEMBL29771054 | 0.75 | CA12 (0.41) | CYP1A2CYP2A6MCL1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287506-B1 | PHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-02-26 | — | — | EP | disclosed |
| EP-1797158-B1 | PHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-05-01 | — | — | EP | disclosed |
| EP-3287506-A1 | PHENANTHRENE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| US-8129037-B2 | Phenanthrene derivative | MERCK PATENT GMBH (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20090026919-A1 | PHENANTHRENE DERIVATIVE | MERCK PATEN GMBH PATENTS & SCIENTIFIC INFORMATION (DE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090026919-A1 | PHENANTHRENE DERIVATIVE | LEF1, CRY1, WNT1 | CYP1A2 66/4885CYP2A6 1440/4885HIF1A 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.