Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.54 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2388362 | 0.93 | RXRA (0.51) | RXRANR1H2NR1H3RETKDM4E | |
| SCHEMBL5793699 | 0.87 | RXRA (0.60) | RXRANR1H2NR1H3RETKDM4E | |
| SCHEMBL5598435 | 0.86 | RXRA (0.51) | RXRANR1H2NR1H3RETKDM4E | |
| SCHEMBL2391072 | 0.83 | RXRA (0.48) | RXRANR1H2NR1H3RETKDM4E | |
| SCHEMBL2390410 | 0.82 | RXRA (0.49) | RXRANR1H2NR1H3RETKDM4E | |
| SCHEMBL4907967 | 0.81 | RXRA (0.58) | RXRANR1H2NR1H3RETKDM4E | |
| SCHEMBL2390155 | 0.81 | RXRA (0.60) | RXRANR1H2NR1H3KDM4EGLA | |
| SCHEMBL2387269 | 0.81 | RXRA (0.53) | RXRANR1H2NR1H3RETKDM4E | |
| SCHEMBL4907809 | 0.80 | RXRA (0.53) | RXRANR1H2NR1H3KDM4EGLA | |
| SCHEMBL2387632 | 0.80 | RXRA (0.59) | RXRANR1H2NR1H3RETKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | disclosed |