Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.51 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.51 |
| ▸ | GNRHR | P30968 | 2/20 | 0.34 |
| ▸ | EIF4EBP1 | Q13541 | 13/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910523 | 0.93 | RXRA (0.50) | RXRANR1H2NR1H3GNRHRRET | |
| SCHEMBL2387170 | 0.92 | RXRA (0.49) | RXRANR1H2NR1H3GNRHRRET | |
| SCHEMBL2385180 | 0.91 | RXRA (0.54) | RXRANR1H2NR1H3GNRHRRET | |
| SCHEMBL5793699 | 0.90 | RXRA (0.60) | RXRANR1H2NR1H3GNRHREIF4EBP1 | |
| SCHEMBL2387124 | 0.90 | RXRA (0.52) | RXRANR1H2NR1H3GNRHRRET | |
| SCHEMBL2389076 | 0.89 | RXRA (0.51) | RXRANR1H2NR1H3GNRHRRET | |
| SCHEMBL5597871 | 0.86 | RXRA (0.54) | RXRANR1H2NR1H3GNRHRRET | |
| SCHEMBL2386392 | 0.85 | RXRA (0.55) | RXRANR1H2NR1H3GNRHRRET | |
| SCHEMBL2388477 | 0.83 | RXRA (0.56) | RXRANR1H2NR1H3GNRHREIF4EBP1 | |
| SCHEMBL2391198 | 0.83 | RXRA (0.49) | RXRANR1H2NR1H3GNRHREIF4EBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006025979-A9 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS INC (US) | 2006-04-20 | — | — | WO | disclosed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | disclosed |