Sugi Predict

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SCHEMBL5597899

SCHEMBL5597899

Cc1ccc(CNS(=O)(=O)c2ccc(OC(F)(F)F)cc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.72
▸ CA12 O43570 1/20 0.61
▸ CYP1A2 P05177 1/20 0.61
▸ CYP3A4 P08684 1/20 0.61
▸ ATM Q13315 1/20 0.61
▸ CA9 Q16790 1/20 0.61
▸ L3MBTL1 Q9Y468 1/20 0.61
▸ BCHE P06276 1/20 0.61
▸ ACHE P22303 1/20 0.61
▸ LMNA P02545 4/20 0.58
▸ HTT P42858 2/20 0.58
▸ SMN1; SMN2 Q16637 2/20 0.58
▸ FFAR4 Q5NUL3 1/20 0.57
▸ CNR2 P34972 1/20 0.57
▸ NAMPT P43490 1/20 0.57
▸ CYP19A1 P11511 1/20 0.56
▸ MEN1 O00255 1/20 0.51
▸ KMT2A Q03164 1/20 0.51
▸ TSHR P16473 2/20 0.51
▸ TP53 P04637 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28004245 1.00 ALDH1A1 (0.72) ALDH1A1CA12CYP1A2CYP3A4ATM
SCHEMBL13972833 0.86 NAMPT (0.55) ALDH1A1CA12CA9BCHEACHE
SCHEMBL13959238 0.86 NAMPT (0.55) ALDH1A1CA9BCHEACHELMNA
SCHEMBL28113867 0.86 CA1 (0.64) ALDH1A1CA12CA9LMNAHTT
SCHEMBL3913276 0.86 NAMPT (0.57) ALDH1A1CA12CA9LMNAHTT
SCHEMBL18450372 0.85 ALDH1A1 (0.68) ALDH1A1CA12CYP1A2CYP3A4ATM
SCHEMBL5518065 0.85 KEAP1 (0.65) ALDH1A1CA12CYP1A2CYP3A4ATM
SCHEMBL25547142 0.84 CA12 (0.83) ALDH1A1CA12CYP1A2CYP3A4ATM
SCHEMBL19636581 0.84 ALDH1A1 (1.00) ALDH1A1CA12CYP1A2CYP3A4ATM
SCHEMBL28003786 0.82 CYP19A1 (0.67) ALDH1A1CA12CYP1A2CYP3A4ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1815860-A2 Phosphate transport inhibitors GENZYME CORPORATION (US) 2007-08-08 — — EP disclosed
US-20070021509-A1 Phosphate transport inhibitors JOZEFIAK THOMAS H 2007-01-25 — — US disclosed
US-20070021509-A1 Phosphate transport inhibitors JOZEFIAK THOMAS H 2007-01-25 — — US disclosed
US-20070021509-A1 Phosphate transport inhibitors JOZEFIAK THOMAS H 2007-01-25 — — US disclosed
US-7119120-B2 Phosphate transport inhibitors GENZYME CORPORATION (US) 2006-10-10 — — US disclosed
EP-1465638-A2 PHOSPHATE TRANSPORT INHIBITORS GENZYME CORPORATION (US) 2004-10-13 — — EP disclosed
US-20040019113-A1 Phosphate transport inhibitors GELTEX PHARMACEUTICALS, INC. 2004-01-29 — — US disclosed
WO-2003057225-A2 PHOSPHATE TRANSPORT INHIBITORS GENZYME CORPORATION (US) 2003-07-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040019113-A1 Phosphate transport inhibitors SLC34A1, SLC34A2, SLC20A1 ALDH1A1 3045/4885CA12 3808/4885CYP1A2 1070/4885
US-20070021509-A1 Phosphate transport inhibitors SLC34A2, SLC34A1, SLC20A1 ALDH1A1 2163/4885CA12 3677/4885CYP1A2 617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.