Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.54 |
| ▸ | RXRA | P19793 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4897920 | 0.87 | NR1H2 (0.62) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL5809163 | 0.86 | RXRA (0.53) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL4902079 | 0.84 | NR1H2 (0.55) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL2266112 | 0.83 | NR1H2 (0.56) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL2389304 | 0.83 | NR1H2 (0.77) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL2263811 | 0.81 | NR1H2 (0.59) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL2264167 | 0.81 | NR1H2 (0.51) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL2264755 | 0.80 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL2262363 | 0.80 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1KDM4E | |
| SCHEMBL12390451 | 0.80 | NR1H2 (0.52) | NR1H2NR1H3RXRAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | claimed |