Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.40 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | TNKS | O95271 | 4/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | POLQ | O75417 | 3/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598041 | 0.95 | NR1H2 (0.40) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL4897419 | 0.89 | NR1H2 (0.42) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL5795184 | 0.85 | RXRA (0.45) | NR1H2NR1H3RXRAMAPTPOLB | |
| SCHEMBL4899624 | 0.84 | NR1H2 (0.41) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL5598263 | 0.84 | NR1H2 (0.39) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL4908027 | 0.84 | NR1H2 (0.47) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL4907807 | 0.80 | NR1H2 (0.47) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL4906529 | 0.80 | NR1H2 (0.48) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL5823324 | 0.79 | NR1H2 (0.43) | NR1H2NR1H3RXRATNKSTNKS2 | |
| SCHEMBL4907759 | 0.79 | NR1H2 (0.43) | NR1H2NR1H3RXRATNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006025979-A9 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS INC (US) | 2006-04-20 | — | — | WO | disclosed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | disclosed |