Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.33 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784831 | 0.88 | KMT2A (0.42) | KMT2AHTTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5599578 | 0.87 | HSD11B1 (0.40) | HTTALDH1A1L3MBTL1GNRHRKCNH2 | |
| SCHEMBL5787489 | 0.85 | HSD11B1 (0.43) | KMT2AALDH1A1MEN1MAPK1 | |
| SCHEMBL5599242 | 0.82 | CYP3A4 (0.38) | KMT2AHTTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5780895 | 0.82 | PSEN1 (0.40) | GNRHRKCNH2 | |
| SCHEMBL5600630 | 0.80 | GNRHR (0.36) | HTTALDH1A1TSHRGNRHRKCNH2 | |
| SCHEMBL5781400 | 0.80 | HSD11B1 (0.35) | GNRHRKCNH2 | |
| SCHEMBL5783881 | 0.80 | TSHR (0.49) | ALDH1A1SMN1; SMN2GAAL3MBTL1TSHR | |
| SCHEMBL5599733 | 0.79 | HSD11B1 (0.40) | HTTALDH1A1SMN1; SMN2L3MBTL1GNRHR | |
| SCHEMBL5600187 | 0.78 | HSD11B1 (0.41) | KMT2ASMN1; SMN2KCNH2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |