Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | GNRHR | P30968 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599242 | 0.93 | CYP3A4 (0.38) | HSD11B1GNRHRKCNH2HTTSMN1; SMN2 | |
| SCHEMBL5600630 | 0.92 | GNRHR (0.36) | CHRM1GNRHRKCNH2CHRM2CHRM3 | |
| SCHEMBL5780895 | 0.90 | PSEN1 (0.40) | HSD11B1CHRM1GNRHRKCNH2CHRM2 | |
| SCHEMBL5600187 | 0.88 | HSD11B1 (0.41) | HSD11B1KCNH2SMN1; SMN2LMNA | |
| SCHEMBL5787489 | 0.86 | HSD11B1 (0.43) | HSD11B1ALDH1A1MGLL | |
| SCHEMBL5599389 | 0.84 | GNRHR (0.40) | HSD11B1CHRM1GNRHRKCNH2CHRM2 | |
| SCHEMBL5599374 | 0.84 | GNRHR (0.40) | HSD11B1CHRM1GNRHRKCNH2CHRM2 | |
| SCHEMBL5781400 | 0.84 | HSD11B1 (0.35) | HSD11B1GNRHRKCNH2PSEN1PSEN2 | |
| SCHEMBL5599358 | 0.84 | PARP1 (0.36) | CHRM1GNRHRKCNH2PSEN1PSEN2 | |
| SCHEMBL5600002 | 0.83 | P2RX7 (0.37) | CHRM1GNRHRKCNH2GRM5PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |