Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 11/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 11/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 11/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 11/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 11/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 11/20 | 0.40 |
| ▸ | GNRHR | P30968 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5600630 | 0.92 | GNRHR (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5599733 | 0.90 | HSD11B1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5599242 | 0.87 | CYP3A4 (0.38) | GNRHRKCNH2HSD11B1 | |
| SCHEMBL5599578 | 0.87 | HSD11B1 (0.40) | GNRHRKCNH2HSD11B1 | |
| SCHEMBL5781400 | 0.86 | HSD11B1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5599358 | 0.86 | PARP1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5599389 | 0.85 | GNRHR (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5599374 | 0.85 | GNRHR (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5783881 | 0.84 | TSHR (0.49) | — | |
| SCHEMBL5783985 | 0.84 | DPP4 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |