Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780777 | 0.86 | CHRM1 (0.40) | CHRM1CHRM3ALDH1A1CHRM2CHRM4 | |
| SCHEMBL5599430 | 0.85 | CHRM1 (0.36) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599106 | 0.85 | CHRM1 (0.40) | CHRM1CHRM3LMNACHRM2CHRM4 | |
| SCHEMBL5785186 | 0.84 | CHRM1 (0.36) | CHRM1CHRM3ALDH1A1LMNACHRM2 | |
| SCHEMBL5779253 | 0.83 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599363 | 0.81 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599828 | 0.81 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599091 | 0.81 | CHRM1 (0.42) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5777458 | 0.81 | CHRM1 (0.35) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599944 | 0.81 | CHRM1 (0.37) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |