Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | CCKBR | P32239 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | FSHR | P23945 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780777 | 0.89 | CHRM1 (0.40) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599287 | 0.85 | CHRM1 (0.36) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5785186 | 0.85 | CHRM1 (0.36) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599106 | 0.84 | CHRM1 (0.40) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5777458 | 0.84 | CHRM1 (0.35) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5779253 | 0.82 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599828 | 0.81 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599363 | 0.81 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599091 | 0.81 | CHRM1 (0.42) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599817 | 0.80 | CHRM1 (0.37) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |