Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | GNRHR | P30968 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599106 | 0.96 | CHRM1 (0.40) | CHRM1CHRM3KCNH2GNRHRCHRM2 | |
| SCHEMBL5779582 | 0.91 | P2RX7 (0.41) | CHRM1CHRM3KCNH2GNRHRP2RX7 | |
| SCHEMBL5780777 | 0.86 | CHRM1 (0.40) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599287 | 0.83 | CHRM1 (0.36) | CHRM1CHRM3KCNH2GNRHRCHRM2 | |
| SCHEMBL5785186 | 0.82 | CHRM1 (0.36) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599430 | 0.82 | CHRM1 (0.36) | CHRM1CHRM3KCNH2GNRHRCHRM2 | |
| SCHEMBL5599363 | 0.81 | CHRM1 (0.38) | CHRM1CHRM3KCNH2GNRHRCHRM2 | |
| SCHEMBL5599828 | 0.81 | CHRM1 (0.38) | CHRM1CHRM3KCNH2GNRHRCHRM2 | |
| SCHEMBL5599091 | 0.81 | CHRM1 (0.42) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5777458 | 0.81 | CHRM1 (0.35) | CHRM1CHRM3KCNH2GNRHRCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |