Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FSHR | P23945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785186 | 0.92 | CHRM1 (0.36) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599553 | 0.91 | PTGDR2 (0.33) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5780777 | 0.88 | CHRM1 (0.40) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599430 | 0.84 | CHRM1 (0.36) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5782575 | 0.84 | GPR183 (0.34) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599106 | 0.84 | CHRM1 (0.40) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599363 | 0.82 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5779253 | 0.81 | CHRM1 (0.38) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599287 | 0.81 | CHRM1 (0.36) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL5599944 | 0.81 | CHRM1 (0.37) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |