Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599341 | 0.90 | TSHR (0.33) | KMT2AMEN1HTR6LMNAGAA | |
| SCHEMBL5599440 | 0.85 | MCHR2 (0.33) | KMT2AMEN1 | |
| SCHEMBL5599346 | 0.83 | KMT2A (0.37) | KMT2ACHRM3GAA | |
| SCHEMBL5599778 | 0.77 | KMT2A (0.39) | KMT2AMEN1LMNA | |
| SCHEMBL5599143 | 0.76 | CYP2C9 (0.37) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5599653 | 0.75 | KMT2A (0.41) | KMT2AMEN1LMNAGAAMAPT | |
| SCHEMBL5781243 | 0.72 | CYP1A2 (0.36) | KMT2ACHRM1CHRM3LMNACYP1A2 | |
| SCHEMBL5578434 | 0.66 | HDAC1 (0.46) | CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4116754 | 0.66 | ACE (0.35) | CYP1A2CYP2C9P2RY1 | |
| SCHEMBL3994423 | 0.65 | DPP9 (0.35) | KMT2ACYP1A2CYP2C9P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |