Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.34 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599143 | 0.91 | CYP2C9 (0.37) | ALDH1A1 | |
| SCHEMBL5599341 | 0.82 | TSHR (0.33) | KMT2AMEN1ALDH1A1TSHRKDM4E | |
| SCHEMBL5599440 | 0.77 | MCHR2 (0.33) | KMT2AMEN1KDM4EUSP2 | |
| SCHEMBL5599671 | 0.77 | KMT2A (0.33) | KMT2AMEN1LMNA | |
| SCHEMBL5599346 | 0.75 | KMT2A (0.37) | KMT2A | |
| SCHEMBL5599653 | 0.72 | KMT2A (0.41) | KMT2AMEN1ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL5785804 | 0.69 | KMT2A (0.36) | KMT2AMEN1ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL5578682 | 0.69 | KMT2A (0.47) | KMT2AMEN1ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL3997885 | 0.66 | KMT2A (0.44) | KMT2AMEN1ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL5635880 | 0.66 | GRIN2B (0.44) | KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |