Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599346 | 0.81 | KMT2A (0.37) | KMT2ASMN1; SMN2GAA | |
| SCHEMBL5599341 | 0.77 | TSHR (0.33) | KMT2AMEN1ALDH1A1KDM4EGAA | |
| SCHEMBL5599671 | 0.75 | KMT2A (0.33) | KMT2AMEN1GAALMNAMAPT | |
| SCHEMBL5599440 | 0.74 | MCHR2 (0.33) | KMT2AMEN1KDM4E | |
| SCHEMBL5599778 | 0.72 | KMT2A (0.39) | KMT2AMEN1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL5578676 | 0.70 | L3MBTL1 (0.49) | KMT2ASMN1; SMN2MEN1NPBWR1MCHR1 | |
| SCHEMBL5599143 | 0.69 | CYP2C9 (0.37) | ALDH1A1 | |
| SCHEMBL4764941 | 0.65 | ALDH1A1 (0.72) | KMT2ASMN1; SMN2MEN1NPBWR1MCHR1 | |
| SCHEMBL5784831 | 0.63 | KMT2A (0.42) | KMT2ASMN1; SMN2MEN1L3MBTL1ALDH1A1 | |
| SCHEMBL5635880 | 0.63 | GRIN2B (0.44) | KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |