Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 2/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779729 | 0.79 | DRD2 (0.36) | DRD1DRD2MAPTGNRHRKCNH2 | |
| SCHEMBL5779471 | 0.72 | POLB (0.37) | MAPTPOLBTSHRHTR1AHTR3A | |
| SCHEMBL7151385 | 0.62 | NPY5R (0.38) | DRD2MAPT | |
| SCHEMBL5592351 | 0.60 | HDAC1 (0.42) | DRD2GNRHRKCNH2HDAC1HDAC6 | |
| SCHEMBL7009460 | 0.60 | HCRTR2 (0.34) | MAPT | |
| SCHEMBL16860861 | 0.58 | NOTUM (0.36) | GNRHRKCNH2 | |
| SCHEMBL20988941 | 0.58 | MAPT (0.69) | MAPT | |
| SCHEMBL8328802 | 0.58 | GNRHR (0.40) | DRD2GNRHRKCNH2 | |
| SCHEMBL12189952 | 0.57 | TNF (0.45) | MAPTPOLBTSHR | |
| SCHEMBL7013385 | 0.57 | NPY5R (0.38) | MAPTGNRHRKCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |