Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | GNRHR | P30968 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599697 | 0.79 | DRD1 (0.35) | DRD2DRD1MAPTGNRHRKCNH2 | |
| SCHEMBL5599732 | 0.75 | SMN1; SMN2 (0.38) | DRD2OPRM1OPRL1SMN1; SMN2EED | |
| SCHEMBL5783494 | 0.74 | LMNA (0.40) | DRD2OPRM1OPRL1SMN1; SMN2SCN9A | |
| SCHEMBL5599820 | 0.72 | SCN9A (0.37) | OPRM1OPRL1SMN1; SMN2SCN9AEED | |
| SCHEMBL5578491 | 0.68 | GLRA3 (0.41) | DRD2DRD1OPRM1OPRL1SMN1; SMN2 | |
| SCHEMBL5578664 | 0.64 | DRD1 (0.41) | DRD2DRD1SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL916973 | 0.60 | FAAH (0.53) | DRD2DRD1SMN1; SMN2EEDMEN1 | |
| SCHEMBL5592351 | 0.58 | HDAC1 (0.42) | DRD2OPRM1SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL14266525 | 0.56 | FAAH (0.44) | DRD2DRD1OPRM1OPRL1SMN1; SMN2 | |
| SCHEMBL16860861 | 0.55 | NOTUM (0.36) | OPRM1OPRL1ALDH1A1NPSR1GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |