Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | CBX7 | O95931 | 1/20 | 0.33 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 3/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599702 | 0.81 | HSD11B1 (0.35) | OPRM1 | |
| SCHEMBL5635671 | 0.81 | EED (0.37) | MEN1KMT2ACBX7CDY1; CDY1BNR1D1 | |
| SCHEMBL5578487 | 0.69 | GRIN2B (0.60) | GRIN2BMEN1KMT2APTGDRPTGDR2 | |
| SCHEMBL5781285 | 0.68 | GRIN2B (0.48) | GRIN2BMEN1KMT2APTGDRPTGDR2 | |
| SCHEMBL5582460 | 0.68 | GRIN2B (0.63) | GRIN2BMEN1KMT2APTGDRPTGDR2 | |
| SCHEMBL5599341 | 0.67 | TSHR (0.33) | MEN1KMT2AKDM4EOPRM1 | |
| SCHEMBL5580211 | 0.66 | AVPR1A (0.43) | MEN1KMT2AAVPR1ACCR5 | |
| SCHEMBL5599778 | 0.66 | KMT2A (0.39) | MEN1KMT2AKDM4E | |
| SCHEMBL5599270 | 0.65 | NOTUM (0.33) | OPRM1OPRD1 | |
| SCHEMBL5599440 | 0.64 | MCHR2 (0.33) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |