Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599833 | 0.94 | HRH3 (0.39) | HRH3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL5599453 | 0.85 | HRH3 (0.43) | HRH3SLC6A4SLC6A2 | |
| SCHEMBL6650639 | 0.78 | POLB (0.39) | HRH3SLC6A4SLC6A2SLC6A3LMNA | |
| SCHEMBL6650451 | 0.77 | LMNA (0.39) | HRH3SLC6A4SLC6A2SLC6A3LMNA | |
| SCHEMBL6648867 | 0.75 | SLC6A4 (0.32) | HRH3SLC6A4SLC6A2SLC6A3LMNA | |
| SCHEMBL6650426 | 0.72 | HRH3 (0.33) | HRH3SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6654163 | 0.71 | HRH3 (0.35) | HRH3SLC6A4SLC6A2SLC6A3LMNA | |
| SCHEMBL5598902 | 0.70 | SLC6A4 (0.39) | HRH3SLC6A4SLC6A2SLC6A3LMNA | |
| SCHEMBL4910298 | 0.69 | HRH3 (0.40) | HRH3SLC6A4SLC6A2SLC6A3LMNA | |
| SCHEMBL6649435 | 0.67 | OPRK1 (0.37) | HRH3SLC6A4SLC6A2SLC6A3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103243-B1 | UTILIZATION OF ARYL(OR HETEROARYL)AZOLYLCARBINOL DERIVATIVES FOR THE TREATMENT OF TROUBLES MEDIATED BY AN EXCESS OF SUBSTANCE P | ESTEVE LABOR DR (ES) | 2004-01-07 | — | — | EP | claimed |
| EP-1746986-A1 | ACTIVE SUBSTANCE COMBINATION COMPRISING A CARBINOL COMBINED TO AT LEAST AN NSAID | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005097099-A1 | ACTIVE SUBSTANCE COMBINATION COMPRISING A CARBINOL COMBINED TO AT LEAST AN NSAID | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-10-20 | — | — | WO | disclosed |