SCHEMBL560225

SCHEMBL560225

FC(F)(F)c1ccc2c(c1)Nc1ccccc1S2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOX1 Q9Y5S8 11/20 1.00
CYBB P04839 2/20 1.00
NOX3 Q9HBY0 2/20 1.00
NOX4 Q9NPH5 2/20 1.00
MAPT P10636 8/20 0.61
GAA P10253 6/20 0.61
USP2 O75604 1/20 0.61
ALOX15 P16050 4/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
SNCA P37840 3/20 0.59
BCHE P06276 2/20 0.59
ACHE P22303 2/20 0.59
TDP1 Q9NUW8 2/20 0.59
CYP1A2 P05177 2/20 0.59
POLB P06746 1/20 0.59
CYP3A4 P08684 1/20 0.59
ADORA3 P0DMS8 1/20 0.59
ALOX12 P18054 1/20 0.59
MAOA P21397 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenothiazine SCHEMBL6532335 1.00 NOX1 (1.00) NOX1CYBBNOX3NOX4MAPT
SCHEMBL29475150 1.00 NOX1 (1.00) NOX1CYBBNOX3NOX4MAPT
Benzene SCHEMBL29242186 0.98 NOX1 (0.97) NOX1CYBBNOX3NOX4MAPT
SCHEMBL10372692 0.91 NOX1 (0.84) NOX1CYBBNOX3NOX4MAPT
SCHEMBL30811565 0.91 NOX1 (0.84) NOX1CYBBNOX3NOX4MAPT
SCHEMBL1855582 0.91 NOX1 (0.83) NOX1CYBBNOX3NOX4MAPT
SCHEMBL25898787 0.83 NOX1 (0.71) NOX1CYBBNOX3NOX4MAPT
SCHEMBL11375009 0.82 NOX1 (0.69) NOX1CYBBNOX3NOX4MAPT
SCHEMBL8881132 0.82 NOX1 (0.68) NOX1CYBBNOX3NOX4MAPT
SCHEMBL9007359 0.82 NOX1 (0.68) NOX1CYBBNOX3NOX4MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 249 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250255879-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) 2025-08-14 US claimed
US-20230330095-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) 2023-10-19 US claimed
EP-4260861-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR Seoul National University R & DB Foundation (KR) 2023-10-18 EP claimed
CN-108484816-B Phenothiazine drug family specific molecularly imprinted polymer, chemiluminescence kit and detection method 河北农业大学 2020-11-06 CN claimed
CN-107406796-B Lubricant for refrigerator and mixed composition for refrigerator 出光兴产株式会社 2020-10-16 CN claimed
EP-3279296-B1 REFRIGERATOR LUBRICATING OIL AND MIXED COMPOSITION FOR REFRIGERATOR IDEMITSU KOSAN CO (JP) 2020-04-29 EP claimed
US-10544380-B2 Refrigerator lubricating oil and mixed composition for refrigerator IDEMITSU KOSAN CO., LTD. (JP) 2020-01-28 US claimed
US-20180057766-A1 REFRIGERATOR LUBRICATING OIL AND MIXED COMPOSITION FOR REFRIGERATOR IDEMITSU KOSAN CO., LTD. (JP) 2018-03-01 US claimed
EP-3279296-A1 REFRIGERATOR LUBRICATING OIL AND MIXED COMPOSITION FOR REFRIGERATOR Idemitsu Kosan Co. Ltd (IKC) (JP) 2018-02-07 EP claimed
US-20170043196-A1 Fire Extinguishing Composition Comprising Heterocyclic Compounds XI'AN J&R FIRE FIGHTING EQUIPMENT CO., LTD. (CN) 2017-02-16 US claimed
EP-3095485-A1 FIRE EXTINGUISHING COMPOSITION COMPRISING HETEROCYCLIC COMPOUNDS Xi'an J&R Fire Fighting Equipment Co., Ltd. (CN) 2016-11-23 EP claimed
CN-105153062-A Preparation method of permitil JIANGSU BAOZONG & BAODA PHARMACHEM CO LTD 2015-12-16 CN claimed
CN-102690245-A Method for preparing trifluoperazine hydrochloride TAICANG HENGYI MEDICAL CHEMICAL RAW MATERIALS PLANT 2012-09-26 CN claimed
US-7897311-B2 Phenothiazine containing photogenerating layer photoconductors XEROX CORPORATION (US) 2011-03-01 US claimed
US-7615312-B2 Electrolytic cells; phenothiazine compound has oxidation potential above positive electrode recharged potential and serves as cyclable redox chemical shuttle providing cell overcharge protection 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-11-10 US claimed
US-20090274969-A1 PHENOTHIAZINE CONTAINING PHOTOGENERATING LAYER PHOTOCONDUCTORS XEROX CORPORATION (US) 2009-11-05 US claimed
EP-1883987-A1 SUBSTITUTED PHENOTHIAZINE REDOX SHUTTLES FOR RECHARGEABLE LITHIUM-ION CELL 3M Innovative Properties Company (US) 2008-02-06 EP claimed
WO-2006124738-A1 SUBSTITUTED PHENOTHIAZINE REDOX SHUTTLES FOR RECHARGEABLE LITHIUM-ION CELL 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-11-23 WO claimed
US-20060263697-A1 Substituted phenothiazine redox shuttles for rechargeable lithium-ion cell 3M INNOVATIVE PROPERTIES COMPANY 2006-11-23 US claimed
US-4249003-A Process for polycyclic amines AKTIEBOLAGET LEO (SE) 1981-02-03 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230330095-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR NUP205, NUP50, NUP188 NOX1 3666/4885CYBB 4601/4885NOX3 4343/4885
US-20250255879-A1 PHARMACEUTICAL COMPOSITION FOR ANTI-CANCER COMPRISING NUPR1 ISOFORM A INHIBITOR NUP205, NUP188, NUP50 NOX1 3568/4885CYBB 4645/4885NOX3 4309/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.