Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 2/20 | 0.70 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.59 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | TTR | P02766 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29912726 | 1.00 | TPMT (0.70) | TPMTHCAR1HCAR2POLBTTR | |
| SCHEMBL8361 | 0.83 | TTR (0.56) | TPMTHCAR1HCAR2POLBTTR | |
| SCHEMBL28214359 | 0.83 | TPMT (1.00) | TPMTHCAR1HCAR2TTRRXRA | |
| SCHEMBL475757 | 0.83 | TTR (0.56) | TPMTHCAR1HCAR2POLBTTR | |
| SCHEMBL69625 | 0.83 | TPMT (0.89) | TPMTHCAR1HCAR2TTRRXRA | |
| SCHEMBL23501889 | 0.83 | TTR (0.56) | TPMTHCAR1HCAR2POLBTTR | |
| SCHEMBL23699 | 0.83 | TPMT (1.00) | TPMTHCAR1HCAR2TTRRXRA | |
| SCHEMBL30973118 | 0.83 | TPMT (0.46) | TPMTHCAR1HCAR2POLBRXRA | |
| SCHEMBL27294868 | 0.83 | TPMT (0.46) | TPMTHCAR1HCAR2POLBRXRA | |
| SCHEMBL986020 | 0.82 | TPMT (0.44) | TPMTHCAR1HCAR2POLBRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263908-A | Preparation of 1-pyridylpyrazole amide compound and intermediate thereof | 湖南化工研究院有限公司 | 2023-12-22 | — | — | CN | claimed |
| CN-1257484-A | Synthesis of intermediates useful in preparing tricyclic compounds | SCHERING CORP (US) | 2000-06-21 | — | — | CN | claimed |
| WO-2024227436-A1 | COMPOUNDS, PREPARATION METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2024-11-07 | — | — | WO | disclosed |
| WO-2024178004-A2 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2024-08-29 | — | — | WO | disclosed |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | ARCUS BIOSCIENCES, INC. | 2024-07-11 | — | — | US | disclosed |
| CN-118239916-A | Polysubstituted benzo dibenzo five-membered ring compound and application thereof | 烟台显华科技集团股份有限公司 | 2024-06-25 | — | — | CN | disclosed |
| CN-118108574-A | Fluorine-containing compound with trimesic structure and application thereof | 烟台显华科技集团股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-111527082-B | Organic electronic device comprising an organic semiconductor layer | 诺瓦尔德股份有限公司 | 2023-07-04 | — | — | CN | disclosed |
| EP-3867237-B1 | PESTICIDALLY ACTIVE AZOLE-AMIDE COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2023-06-07 | — | — | EP | disclosed |
| CN-111032034-B | Spiro compounds and methods of making and using the same | H.隆德贝克有限公司 | 2023-05-02 | — | — | CN | disclosed |
| US-11462691-B2 | Organic electronic device comprising an organic semiconductor layer | NOVALED GMBH (DE) | 2022-10-04 | — | — | US | disclosed |
| WO-2007146838-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-21 | — | — | WO | disclosed |
| US-20070099885-A1 | Antibacterial macrocycles with substituted biphenyl | AICURIS GMBH & CO. KG (DE) | 2007-05-03 | — | — | US | disclosed |
| EP-1697400-A1 | BIPHENYL-SUBSTITUTED ANTIBACTERIAL MACROCYCLES | AiCuris GmbH & Co. KG (DE) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058943-A1 | BIPHENYL-SUBSTITUTED ANTIBACTERIAL MACROCYCLES | AICURIS GMBH & CO. KG (DE) | 2005-06-30 | — | — | WO | disclosed |
| CN-1178919-C | Synthesis of intermediates useful in preparing tricyclic compounds | ���鹫˾ | 2004-12-08 | — | — | CN | disclosed |
| CN-1257484-A | Synthesis of intermediates useful in preparing tricyclic compounds | SCHERING CORP (US) | 2000-06-21 | — | — | CN | disclosed |
| US-5866610-A | Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellular NA+/H+ exchange or as a diagnostic, and pharmaceutical containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-02 | — | — | US | disclosed |
| EP-0612723-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AG (DE) | 1997-08-27 | — | — | EP | disclosed |
| EP-0612723-A1 | Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-08-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099885-A1 | Antibacterial macrocycles with substituted biphenyl | NOD2, AHR, BCL2 | TPMT 297/4885HCAR1 1376/4885HCAR2 1651/4885 |
| US-20240226115-A1 | AXL INHIBITOR COMPOUNDS | AXL, BTK, MERTK | TPMT 1228/4885HCAR1 2532/4885HCAR2 2955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.