Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5600258 | 0.81 | RAB9A (0.35) | RAB9AKCNMA1SMN1; SMN2ACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL5603220 | 0.81 | RAB9A (0.43) | RAB9AKCNMA1SMN1; SMN2ACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL5601924 | 0.81 | RAB9A (0.43) | RAB9AKCNMA1SMN1; SMN2ACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL5603327 | 0.79 | RAB9A (0.33) | RAB9AKCNMA1SMN1; SMN2ACHEALDH1A1 | |
| SCHEMBL5603229 | 0.77 | RAB9A (0.39) | RAB9AKCNMA1SMN1; SMN2ACHEALDH1A1 | |
| SCHEMBL5601936 | 0.77 | RAB9A (0.39) | RAB9AKCNMA1SMN1; SMN2ACHEALDH1A1 | |
| SCHEMBL5603604 | 0.77 | SMN1; SMN2 (0.40) | RAB9AKCNMA1SMN1; SMN2ACHEALDH1A1 | |
| Hydrochloric Acid SCHEMBL5602758 | 0.75 | LRRK2 (0.36) | CYP1A2GAAMAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL5603648 | 0.75 | POLB (0.44) | ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL5601294 | 0.75 | KDM4E (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | disclosed |
| US-20050261449-A1 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENT INC. | 2005-11-24 | — | — | US | disclosed |