Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14525478 | 1.00 | CYP19A1 (0.42) | CYP19A1CYP11B1CYP11B2HSD11B1SIRT2 | |
| SCHEMBL14525475 | 0.76 | DPP4 (0.47) | CYP19A1CYP11B1CYP11B2HSD11B1SIRT2 | |
| SCHEMBL5604691 | 0.76 | DPP4 (0.47) | CYP19A1CYP11B1CYP11B2HSD11B1SIRT2 | |
| SCHEMBL5604306 | 0.73 | HSD11B1 (0.44) | CYP19A1CYP11B1CYP11B2HSD11B1SIRT2 | |
| SCHEMBL14525476 | 0.73 | HSD11B1 (0.44) | CYP19A1CYP11B1CYP11B2HSD11B1SIRT2 | |
| SCHEMBL14525480 | 0.71 | HSD11B1 (0.43) | HSD11B1SIRT2SIRT1L3MBTL1DPP4 | |
| SCHEMBL5603303 | 0.71 | HSD11B1 (0.43) | HSD11B1SIRT2SIRT1L3MBTL1DPP4 | |
| SCHEMBL28024099 | 0.66 | FAAH (0.63) | CYP19A1CYP11B1CYP11B2L3MBTL1FAAH | |
| SCHEMBL20804353 | 0.66 | FAAH (0.63) | CYP19A1CYP11B1CYP11B2L3MBTL1FAAH | |
| SCHEMBL27993462 | 0.64 | HSD11B1 (0.42) | CYP19A1CYP11B1CYP11B2HSD11B1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205322-B2 | Thiazolidine compounds as calcium sensing receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| US-20040242602-A1 | Novel thiazolidine compounds as calcium sensing receptor modulators | BRISTOL-MYERS SQUIBB COMPANY | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242602-A1 | Novel thiazolidine compounds as calcium sensing receptor modulators | CASR, RYR1, CACNA1E | CYP19A1 1400/4885CYP11B1 1445/4885CYP11B2 1873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.