Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.48 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122427 | 0.79 | KMT2A (0.77) | KMT2APKMLMNAALDH1A1MEN1 | |
| SCHEMBL1122431 | 0.79 | KMT2A (0.77) | KMT2APKMLMNAALDH1A1MEN1 | |
| SCHEMBL5333467 | 0.77 | HSP90AA1 (0.41) | KMT2APKMKEAP1LMNAALDH1A1 | |
| SCHEMBL27952528 | 0.77 | KEAP1 (0.54) | KMT2APKMKEAP1CA1CA2 | |
| SCHEMBL7446297 | 0.76 | KEAP1 (0.58) | KMT2APKMKEAP1CA1CA2 | |
| SCHEMBL28046088 | 0.76 | KEAP1 (0.52) | KMT2APKMKEAP1CA1CA2 | |
| SCHEMBL1424434 | 0.76 | TGM2 (0.64) | KMT2APKMKEAP1CA1CA2 | |
| SCHEMBL2103296 | 0.72 | KEAP1 (0.58) | KMT2APKMKEAP1CA1CA2 | |
| SCHEMBL59151 | 0.71 | KEAP1 (0.64) | KMT2APKMKEAP1CA1CA2 | |
| SCHEMBL6005110 | 0.71 | CA2 (0.64) | KMT2APKMKEAP1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070816-A2 | THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | disclosed |