Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.78 |
| ▸ | ESR2 | Q92731 | 15/20 | 0.78 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669065 | 0.88 | ESR1 (1.00) | ESR1ESR2MLNRNR1I2NR3C1 | |
| Hydrochloric Acid SCHEMBL3776559 | 0.87 | ESR1 (0.98) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL30583267 | 0.87 | ESR1 (1.00) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL4325515 | 0.87 | ESR1 (1.00) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL19439314 | 0.86 | ESR1 (0.78) | ESR1ESR2 | |
| SCHEMBL20234943 | 0.85 | ESR1 (0.84) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL15038137 | 0.83 | ESR1 (0.66) | ESR1ESR2 | |
| SCHEMBL22297087 | 0.83 | ESR1 (0.80) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20211899 | 0.83 | ESR1 (0.80) | ESR1ESR2MLNRNR1I2NR3C1 | |
| SCHEMBL20143171 | 0.83 | ESR1 (0.73) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7255984-B2 | Combination therapy for osteoporosis | PFIZER INC. (US) | 2007-08-14 | — | — | US | disclosed |
| US-6482825-B2 | HEXAHYDRO-PYRAZOLO-(4,3-C)PYRIDINE DERIVATIVES USEFUL FOR INCREASING THE ENDOGENOUS PRODUCTION OR RELEASE OF GROWTH HORMONE IN A HUMAN OR OTHER ANIMAL, THUS TREAT OR PREVENT OSTEOPOROSIS | PFIZER INC. | 2002-11-19 | — | — | US | disclosed |
| US-20020049196-A1 | Growth-hormone secretagogues | RAQUALIA PHARMA INC. (JP) | 2002-04-25 | — | — | US | disclosed |
| US-20010018451-A1 | Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions | MACLEAN DAVID B (US) | 2001-08-30 | — | — | US | disclosed |
| US-20010009920-A1 | Estrogen agonist/antagonist and a prostaglandin or a prostaglandin agonist/antagonist | KE HUA ZHU (US) | 2001-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010009920-A1 | Estrogen agonist/antagonist and a prostaglandin or a prostaglandin agonist/antagonist | PTGER1, PTGER2, PTGER4 | ESR1 7/4885ESR2 6/4885GRIN1 1019/4885 |
| US-20010018451-A1 | Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions | GPER1, ESR2, ESR1 | ESR1 3/4885ESR2 2/4885GRIN1 392/4885 |
| US-20020049196-A1 | Growth-hormone secretagogues | GHSR, GHRHR, IGFBP6 | ESR1 278/4885ESR2 233/4885GRIN1 1919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.