SCHEMBL5605863

SCHEMBL5605863

COc1ccc(C(CS(C)(=O)=O)S(=O)(=O)Cc2ccc(C)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
MAPT P10636 3/20 0.46
NPC1 O15118 2/20 0.46
LMNA P02545 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
RAB9A P51151 2/20 0.46
KDM4E B2RXH2 1/20 0.46
MEN1 O00255 1/20 0.46
GAA P10253 1/20 0.46
HTT P42858 1/20 0.46
KMT2A Q03164 1/20 0.46
ACHE P22303 2/20 0.44
BCHE P06276 1/20 0.44
EGFR P00533 1/20 0.43
UTS2R Q9UKP6 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
APLNR P35414 1/20 0.40
TDP1 Q9NUW8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5047503 0.73 CNR2 (0.53) ALDH1A1SMN1; SMN2MEN1KMT2AEGFR
SCHEMBL2377998 0.72 APLNR (0.58) ALDH1A1SMN1; SMN2HTTKMT2AL3MBTL1
SCHEMBL171784 0.71 LDHA (0.50) ALDH1A1MEN1HTTKMT2AACHE
SCHEMBL3824255 0.70 CA1 (0.43) ALDH1A1NPC1SMN1; SMN2RAB9AHTT
SCHEMBL752330 0.70 LDHA (0.49) ALDH1A1SMN1; SMN2HTTKMT2AAPLNR
SCHEMBL752240 0.70 PLCG1 (0.49) ALDH1A1HTTKMT2AACHEL3MBTL1
SCHEMBL28748830 0.68 AOC3 (0.53) ALDH1A1MAPTGAAACHEAPLNR
SCHEMBL21115782 0.68 CYP1A2 (0.56) ALDH1A1MAPTKDM4EACHEAPLNR
SCHEMBL28748864 0.68 AOC3 (0.53) ALDH1A1MAPTGAAACHEAPLNR
SCHEMBL13926854 0.67 SLC6A4 (0.49) ALDH1A1SMN1; SMN2MEN1HTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1761485-A1 AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS Schering AG (DE) 2007-03-14 EP disclosed
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed
WO-2004108661-A1 AMIDINO COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS AXYS PHARMACEUTICALS (US) 2004-12-16 WO disclosed