Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607313 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL3487663 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL4692190 | 0.70 | NR1H2 (0.45) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL3487918 | 0.69 | SMN1; SMN2 (0.38) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL11687990 | 0.69 | GAA (0.61) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL3487585 | 0.69 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL4478931 | 0.68 | ASAH1 (0.35) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL5607055 | 0.63 | DGAT1 (0.48) | SMN1; SMN2KDM4EGAALMNAHSD17B10 | |
| SCHEMBL1390692 | 0.63 | KDM4E (1.00) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL30402838 | 0.63 | KDM4E (1.00) | SMN1; SMN2ALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |