Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606136 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL5606238 | 0.78 | PGR (0.38) | ALDH1A1HPGDNPC1RAB9AP2RX3 | |
| SCHEMBL5657430 | 0.77 | EPHX1 (0.40) | NPC1RAB9AP2RX3MAPT | |
| SCHEMBL3487918 | 0.76 | SMN1; SMN2 (0.38) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL5613996 | 0.72 | MAPT (0.46) | SMN1; SMN2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL5613761 | 0.72 | PSMB8 (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA | |
| SCHEMBL5613942 | 0.71 | BPTF (0.43) | — | |
| SCHEMBL5606522 | 0.71 | PLK1 (0.41) | SMN1; SMN2ALDH1A1GAAHDAC3MEN1 | |
| SCHEMBL5607253 | 0.71 | MAPT (0.38) | ALDH1A1LMNAP2RX3MEN1KMT2A | |
| SCHEMBL17844161 | 0.70 | FAAH (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | claimed |