Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.32 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605796 | 0.86 | MAPK14 (0.40) | LMNAMAOAALDH1A1MAPTHPGD | |
| SCHEMBL4597402 | 0.83 | KDM4E (0.39) | LMNAMAOAALDH1A1MAPTHPGD | |
| SCHEMBL4597398 | 0.82 | LMNA (0.36) | LMNAMAOAALDH1A1MAPTHPGD | |
| SCHEMBL4226195 | 0.80 | PRKAB2 (0.51) | LMNAMAOAALDH1A1MAPTHPGD | |
| SCHEMBL5605458 | 0.78 | MAPK14 (0.38) | ALDH1A1MAPTKDM4EGAAMAPK1 | |
| SCHEMBL5606145 | 0.78 | BRD4 (0.37) | LMNAMAOAALDH1A1MAPTHPGD | |
| SCHEMBL5606037 | 0.78 | DPP4 (0.37) | ALDH1A1MAPTKDM4EGAAMAPK1 | |
| SCHEMBL5605916 | 0.78 | MAPT (0.35) | LMNAALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL4223573 | 0.78 | AQP1 (0.47) | LMNAMAOAALDH1A1MAPTHPGD | |
| SCHEMBL4223586 | 0.78 | PRKAB2 (0.42) | LMNAMAOAALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |