Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 4/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 4/20 | 0.35 |
| ▸ | LIPE | Q05469 | 2/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606425 | 1.00 | WDR5 (0.40) | WDR5ROCK2TRPV4BRD9LIPE | |
| SCHEMBL1737840 | 1.00 | WDR5 (0.40) | WDR5ROCK2TRPV4BRD9LIPE | |
| SCHEMBL1738857 | 0.84 | OPRM1 (0.41) | ROCK2BRD9BRPF1BRD4KAT2B | |
| SCHEMBL1737776 | 0.84 | OPRM1 (0.41) | ROCK2BRD9BRPF1BRD4KAT2B | |
| SCHEMBL1738620 | 0.84 | OPRM1 (0.41) | ROCK2BRD9BRPF1BRD4KAT2B | |
| SCHEMBL1737229 | 0.82 | ROCK2 (0.42) | ROCK2BRD9BRPF1BRD4KAT2B | |
| SCHEMBL1738449 | 0.82 | ROCK2 (0.42) | ROCK2BRD9BRPF1BRD4KAT2B | |
| SCHEMBL1738781 | 0.82 | ROCK2 (0.42) | ROCK2BRD9BRPF1BRD4KAT2B | |
| SCHEMBL12295012 | 0.79 | ROCK2 (0.41) | ROCK2BRD9BRPF1BRD4BRD7 | |
| SCHEMBL12295018 | 0.79 | ROCK2 (0.41) | ROCK2BRD9BRPF1BRD4BRD7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007026219-A2 | COMBINATIONS OF A 5-HT1B ANTAGONIST WITH A NORADRENALIN RE-UPTAKE INHIBITOR OR A SEROTONIN NORADRENALIN REUTAKE INHIBITOR FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007026224-A2 | 5-HT1B ANTAGONIST COMPOSITION FOR DEPRESSION, ANXIETY AND COGNITION | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007026219-A2 | COMBINATIONS OF A 5-HT1B ANTAGONIST WITH A NORADRENALIN RE-UPTAKE INHIBITOR OR A SEROTONIN NORADRENALIN REUTAKE INHIBITOR FOR TREATING CNS CONDITIONS | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007026224-A2 | 5-HT1B ANTAGONIST COMPOSITION FOR DEPRESSION, ANXIETY AND COGNITION | PFIZER PRODUCTS INC. (US) | 2007-03-08 | — | — | WO | disclosed |