Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28322681 | 0.83 | ADORA3 (0.40) | RIPK1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL17065188 | 0.83 | MAPK1 (0.51) | RIPK1MAPK1MEN1KMT2ANPC1 | |
| SCHEMBL30352947 | 0.82 | CDK8 (0.54) | MAPK1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL20508757 | 0.81 | PIK3CD (0.56) | RIPK1MAPK1NPC1ALOX5APFEN1 | |
| SCHEMBL845813 | 0.76 | CDK8 (0.37) | RIPK1MAPK1DYRK1BALOX5APFEN1 | |
| SCHEMBL844875 | 0.75 | MAPK1 (0.53) | RIPK1MAPK1ALOX5APFEN1AXL | |
| SCHEMBL17065175 | 0.73 | MAP3K11 (0.46) | MAPK1MAPTDYRK1ADYRK2DYRK1B | |
| SCHEMBL22978455 | 0.72 | RIPK1 (1.00) | RIPK1MAPK1DYRK1ADYRK2DYRK1B | |
| SCHEMBL5103665 | 0.72 | HRH3 (0.47) | MAPK1 | |
| SCHEMBL20162798 | 0.72 | FEN1 (0.41) | RIPK1MAPK1DYRK1BALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781298-A1 | PHARMACEUTICAL COMBINATIONS CONTAINING BENZOXAZINE FOR TREATING RESPIRATORY DISEASES | Boehringer Ingelheim International GmbH (DE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005102349-A1 | PHARMACEUTICAL COMBINATIONS CONTAINING BENZOXAZINE FOR TREATING RESPIRATORY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-03 | — | — | WO | disclosed |