Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 3/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.31 |
| ▸ | PARG | Q86W56 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1546570 | 0.82 | PDE5A (0.46) | LMNASMN1; SMN2HPGDGRIN2AGRIA2 | |
| SCHEMBL1546537 | 0.69 | LMNA (0.51) | LMNASMN1; SMN2HPGDGRIN2AGRIA2 | |
| SCHEMBL2333544 | 0.69 | LMNA (0.52) | LMNASMN1; SMN2HPGDPDE5APDE4A | |
| SCHEMBL240142 | 0.65 | LMNA (0.51) | LMNASMN1; SMN2HPGDPDE4APDE4B | |
| SCHEMBL2756837 | 0.65 | LMNA (0.51) | LMNASMN1; SMN2HPGDPDE4APDE4B | |
| SCHEMBL1546588 | 0.64 | ALDH1A1 (0.50) | LMNASMN1; SMN2GRIN2AGRIA2PDE5A | |
| SCHEMBL4639746 | 0.63 | LMNA (0.49) | LMNASMN1; SMN2HPGDCNR2PDE4A | |
| SCHEMBL1546128 | 0.63 | LMNA (0.46) | LMNASMN1; SMN2HPGDALDH1A1L3MBTL1 | |
| SCHEMBL17434511 | 0.63 | NOTUM (0.50) | LMNASMN1; SMN2GRIN2AGRIA2PDE5A | |
| SCHEMBL2543060 | 0.63 | LMNA (0.45) | LMNASMN1; SMN2HPGDALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799221-A1 | METHOD OF PREVENTING AND TREATING AIRWAY REMODELING AND PULMONARY INFLAMMATION USING A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044610-A1 | METHOD OF PREVENTING AND TREATING AIRWAY REMODELING AND PULMONARY INFLAMMATION USING A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC (US) | 2006-04-27 | — | — | WO | disclosed |