Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996996 | 0.90 | SGMS2 (0.38) | TRPV1ALDH1A1SMN1; SMN2SGMS2ROCK2 | |
| SCHEMBL2000314 | 0.88 | SGMS2 (0.41) | SGMS2ROCK2VNN1 | |
| SCHEMBL1995971 | 0.86 | TRPV1 (0.43) | TRPV1KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5607826 | 0.85 | TRPV1 (0.47) | TRPV1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL1997048 | 0.84 | POLB (0.43) | TRPV1KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL1994497 | 0.82 | MMP1 (0.41) | KDM4EALDH1A1GAASMN1; SMN2ROCK2 | |
| SCHEMBL2001626 | 0.82 | TRPV1 (0.39) | TRPV1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2001436 | 0.81 | TRPV1 (0.42) | TRPV1ALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL5607985 | 0.81 | TRPV1 (0.37) | TRPV1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL1997464 | 0.81 | TDP1 (0.40) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123692-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | claimed |