Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 20/20 | 0.92 |
| ▸ | PPARG | P37231 | 13/20 | 0.92 |
| ▸ | PPARD | Q03181 | 11/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5993963 | 1.00 | PPARA (0.92) | PPARAPPARGPPARD | |
| SCHEMBL16415813 | 1.00 | PPARA (0.92) | PPARAPPARGPPARD | |
| Water SCHEMBL7212115 | 0.97 | PPARA (0.88) | PPARAPPARGPPARD | |
| Water SCHEMBL7212110 | 0.96 | PPARA (0.86) | PPARAPPARGPPARD | |
| SCHEMBL8805008 | 0.93 | PPARA (0.80) | PPARAPPARGPPARD | |
| SCHEMBL8805888 | 0.93 | PPARA (0.80) | PPARAPPARGPPARD | |
| SCHEMBL5607130 | 0.89 | PPARA (0.75) | PPARAPPARGPPARD | |
| SCHEMBL15811673 | 0.89 | PPARA (0.75) | PPARAPPARGPPARD | |
| SCHEMBL4758109 | 0.89 | PPARA (0.75) | PPARAPPARGPPARD | |
| SCHEMBL5338861 | 0.89 | PPARA (0.75) | PPARAPPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084101-B1 | NEW 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVE III | ASTRAZENECA AB (SE) | 2004-03-10 | — | — | EP | claimed |
| EP-3004053-B1 | A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES | CADILA HEALTHCARE LTD (IN) | 2021-03-24 | — | — | EP | disclosed |
| US-10435363-B2 | Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities | CADILA HEALTHCARE LIMITED (IN) | 2019-10-08 | — | — | US | disclosed |
| US-20170144968-A1 | PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES | ZYDUS LIFESCIENCES LIMITED (IN) | 2017-05-25 | — | — | US | disclosed |
| US-20160107989-A1 | A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES | CADILA HEALTHCARE LIMITED (IN) | 2016-04-21 | — | — | US | disclosed |
| US-20160051529-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES | CIRIUS THERAPEUTICS, INC. | 2016-02-25 | — | — | US | disclosed |
| EP-2931274-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | Metabolic Solutions Development Company LLC (US) | 2015-10-21 | — | — | EP | disclosed |
| WO-2014093114-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY LLC (US) | 2014-06-19 | — | — | WO | disclosed |
| WO-2012177956-A1 | PPAR-SPARING COMPOUNDS FOR USE IN THE TREATMENT OF DIABETES AND OTHER METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMAPNY, LLC (US) | 2012-12-27 | — | — | WO | disclosed |
| US-20070142472-A1 | Process for producing optically active 3-(4-hydroxyphenyl)proprionic acids | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-06-21 | — | — | US | disclosed |
| WO-2001040159-A1 | NEW PROCESS | ASTRAZENECA AB (SE) | 2001-06-07 | — | — | WO | disclosed |
| EP-1084103-A1 | NEW 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVE (I) | AstraZeneca AB (SE) | 2001-03-21 | — | — | EP | disclosed |
| EP-1084102-A1 | NEW 3-ARYL PROPIONIC ACID DERIVATIVES AND ANALOGS | AstraZeneca AB (SE) | 2001-03-21 | — | — | EP | disclosed |
| EP-1084101-A1 | NEW 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVE III | AstraZeneca AB (SE) | 2001-03-21 | — | — | EP | disclosed |
| WO-2001011073-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 3-PHENYL-PROPANOIC ACID ESTERS AND SUBSTITUTED 3-PHENYL-PROPANOIC ACIDS | NOVO NORDISK A/S (DK) | 2001-02-15 | — | — | WO | disclosed |
| WO-2001011072-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 3-PHENYL-PROPANOIC ACID ESTERS AND SUBSTITUTED 3-PHENYL-PROPANOIC ACIDS | NOVO NORDISK A/S (DK) | 2001-02-15 | — | — | WO | disclosed |
| WO-2000026200-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF NEW ANTIDIABETIC AGENTS | DR. REDDY'S RESEARCH FOUNDATION (IN) | 2000-05-11 | — | — | WO | disclosed |
| WO-1999062870-A1 | NEW 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVE III | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999062871-A1 | NEW 3-ARYL PROPIONIC ACID DERIVATIVES AND ANALOGS | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
| WO-1999062872-A1 | NEW 3-ARYL-2-HYDROXYPROPIONIC ACID DERIVATIVE (I) | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160051529-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES | PPARD, PPARG, PPARA | PPARA 3/4885PPARG 2/4885PPARD 1/4885 |
| US-20160107989-A1 | A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES | CYP51A1, DHCR7, LIPA | PPARA 418/4885PPARG 598/4885PPARD 470/4885 |
| US-20170144968-A1 | PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES | CYP51A1, LIPA, DHCR7 | PPARA 418/4885PPARG 678/4885PPARD 450/4885 |
| US-10435363-B2 | Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities | CYP51A1, LIPA, DHCR7 | PPARA 418/4885PPARG 678/4885PPARD 450/4885 |
| US-20070142472-A1 | Process for producing optically active 3-(4-hydroxyphenyl)proprionic acids | ALDH1A2, ALDH1A3, GRHPR | PPARA 472/4885PPARG 1052/4885PPARD 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.