Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997127 | 0.94 | GAA (0.39) | TRPV1GAAMAPK1STING1 | |
| SCHEMBL1996126 | 0.93 | KDM4C (0.36) | TRPV1GAAMAPK1STING1 | |
| SCHEMBL5607367 | 0.80 | DHODH (0.40) | TRPV1 | |
| SCHEMBL5607666 | 0.80 | DHODH (0.37) | TRPV1 | |
| SCHEMBL5607679 | 0.79 | PDE4B (0.36) | TRPV1 | |
| SCHEMBL5607826 | 0.79 | TRPV1 (0.47) | TRPV1 | |
| SCHEMBL1997921 | 0.78 | CDC25B (0.44) | MAPK1 | |
| SCHEMBL5607985 | 0.77 | TRPV1 (0.37) | TRPV1 | |
| SCHEMBL1994571 | 0.75 | ADORA3 (0.40) | — | |
| SCHEMBL1994786 | 0.74 | PDE4A (0.40) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123692-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | disclosed |