Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607666 | 0.97 | DHODH (0.37) | DHODHTRPV1GABRA1GABRG2GABRB3 | |
| SCHEMBL1997594 | 0.94 | GABRA1 (0.40) | TRPV1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1996488 | 0.93 | DHODH (0.44) | DHODHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1992169 | 0.92 | ADRA2A (0.39) | TRPV1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1998992 | 0.88 | DHODH (0.38) | DHODHAURKARPS6KB1KDM4CALDH1A1 | |
| SCHEMBL1994571 | 0.85 | ADORA3 (0.40) | AURKARPS6KB1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL5607826 | 0.83 | TRPV1 (0.47) | TRPV1RPS6KB1KMT2ASMN1; SMN2PDE4B | |
| SCHEMBL1994512 | 0.82 | ALDH1A1 (0.39) | DHODHAURKARPS6KB1KDM4CALDH1A1 | |
| SCHEMBL5607679 | 0.81 | PDE4B (0.36) | TRPV1ALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1997921 | 0.81 | CDC25B (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123692-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | disclosed |