SCHEMBL5608221

SCHEMBL5608221

COC1(Br)c2ccccc2CC1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 3/20 0.38
CYP3A4 P08684 2/20 0.36
MEN1 O00255 1/20 0.36
CYP2D6 P10635 1/20 0.36
ALOX15 P16050 1/20 0.36
CYP2C19 P33261 1/20 0.36
KMT2A Q03164 1/20 0.36
GRIN2D O15399 1/20 0.36
GRIN3B O60391 1/20 0.36
BCHE P06276 1/20 0.36
CHRM5 P08912 1/20 0.36
TSHR P16473 1/20 0.36
ALOX12 P18054 1/20 0.36
NFKB1 P19838 1/20 0.36
MAPK1 P28482 1/20 0.36
PRCP P42785 1/20 0.36
GRIN1 Q05586 1/20 0.36
GRIN2A Q12879 1/20 0.36
GRIN2B Q13224 1/20 0.36
GRIN2C Q14957 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8734065 0.78 SIGMAR1 (0.40) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
SCHEMBL28280087 0.74 CYP3A4 (0.38) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
SCHEMBL414650 0.71 CYP3A4 (0.44) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
Benzene SCHEMBL28485309 0.69 SIGMAR1 (0.44) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
Hydrochloric Acid SCHEMBL28152573 0.69 CYP3A4 (0.43) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
SCHEMBL9053824 0.69 KDM1A (0.41) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
SCHEMBL3455254 0.68 CYP3A4 (0.42) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
SCHEMBL2466865 0.68 KDM1A (0.43) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
SCHEMBL10595033 0.68 CYP3A4 (0.42) SIGMAR1CYP3A4MEN1CYP2D6ALOX15
SCHEMBL6985972 0.68 CYP3A4 (0.42) SIGMAR1CYP3A4MEN1CYP2D6ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1833859-A2 HALOGEN SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION ExxonMobil Chemical Patents Inc. (US) 2007-09-19 EP disclosed
WO-2006065843-A2 HALOGEN SUBSTITUTED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-06-22 WO disclosed
WO-2006065809-A2 HETEROATOM BRIDGED METALLOCENE COMPOUNDS FOR OLEFIN POLYMERIZATION EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-06-22 WO disclosed