Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.45 |
| ▸ | ITGAL | P20701 | 1/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29615516 | 0.84 | HPGD (0.56) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL29437007 | 0.81 | HPGD (0.61) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL229498 | 0.81 | HPGD (0.61) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL566636 | 0.81 | HPGD (0.61) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL1300333 | 0.81 | HPGD (0.61) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3885955 | 0.80 | HPGD (0.59) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7528728 | 0.80 | HPGD (0.59) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7526056 | 0.80 | HPGD (0.59) | HPGDHTTCYP2C19SMN1; SMN2ALDH1A1 | |
| Fluoride SCHEMBL30783508 | 0.77 | HPGD (0.48) | HPGDHTTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL229558 | 0.75 | HPGD (0.49) | HPGDHTTSMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-A1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | Novartis AG (CH) | 2007-12-12 | — | — | EP | claimed |
| WO-2006100036-A1 | 3, 4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2006-09-28 | — | — | WO | claimed |