Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29437007 | 1.00 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| SCHEMBL1300333 | 1.00 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| SCHEMBL229498 | 1.00 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| Hydrochloric Acid SCHEMBL7526056 | 0.98 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| Hydrochloric Acid SCHEMBL7528728 | 0.98 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| Hydrochloric Acid SCHEMBL3885955 | 0.98 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| SCHEMBL29615516 | 0.95 | HPGD (0.56) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| SCHEMBL3568567 | 0.86 | HPGD (0.63) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| SCHEMBL1567597 | 0.85 | HPGD (0.61) | HPGDALDH1A1SMN1; SMN2NISCHHTT | |
| SCHEMBL30946854 | 0.85 | NISCH (0.71) | HPGDALDH1A1SMN1; SMN2NISCHHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999741-B2 | Process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one | CARDURION PHARMACEUTICALS, INC. (US) | 2024-06-04 | — | — | US | claimed |
| CN-117105931-A | Method for preparing pyridopyrimidine compounds and intermediate thereof | 上海翰森生物医药科技有限公司 | 2023-11-24 | — | — | CN | claimed |
| CN-117004679-A | Molecular evolution and catalytic synthesis of (S) -1, 4-benzodioxane by candida antarctica lipase B | 上海交通大学 | 2023-11-07 | — | — | CN | claimed |
| US-20230122169-A1 | NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE | CELLTRION, INC. (KR) | 2023-04-20 | — | — | US | claimed |
| EP-3858816-A1 | NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE | Celltrion, Inc. (KR) | 2021-08-04 | — | — | EP | claimed |
| WO-2020067684-A1 | NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE | (주)셀트리온 | 2020-04-02 | — | — | WO | claimed |
| WO-2020067683-A1 | NOVEL PROCESS FOR THE PREPARATION OF (+)-CIBENZOLINE SUCCINATE | CELLTRION INC. (KR) | 2020-04-02 | — | — | WO | claimed |
| CN-108250177-B | A kind of preparation method of 1,4- benzdioxan -2- formic acid | 上海馨远医药科技有限公司 | 2019-05-17 | — | — | CN | claimed |
| CN-101619059-B | Method for preparing osemozotan hydrochloride | JIANGSU ENHUA PHARMACEUTICAL CO LTD | 2011-09-14 | — | — | CN | claimed |
| EP-2215054-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2010-08-11 | — | — | EP | claimed |
| CN-101619059-A | Method for preparing osemozotan hydrochloride | NHWA PHARMACEUTICAL GROUP CO L | 2010-01-06 | — | — | CN | claimed |
| CN-100534989-C | Resolving process of (RS)-benzdioxan-2-formic acid | SHANGHAI INST OF CHEMICAL REAG (CN) | 2009-09-02 | — | — | CN | claimed |
| WO-2009064449-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2009-05-22 | — | — | WO | claimed |
| CN-1986541-A | Resolving process of (RS)-benzdioxan-2-formic acid | SHANGHAI INST OF CHEMICAL REAG (CN) | 2007-06-27 | — | — | CN | claimed |
| EP-0833937-B1 | OPTICAL RESOLUTION OF ALKYL 1,4-BENZODIOXAN-2-CARBOXYLATES USING ESTERASE FROM SERRATIA MARCESCENS | SEPRACOR INC (US) | 2002-01-23 | — | — | EP | claimed |
| EP-0833937-A1 | OPTICAL RESOLUTION OF ALKYL 1,4-BENZODIOXAN-2-CARBOXYLATES USING ESTERASE FROM SERRATIA MARCESCENS | Seprachem, Inc. (US) | 1998-04-08 | — | — | EP | claimed |
| WO-1996040976-A1 | OPTICAL RESOLUTION OF ALKYL 1,4-BENZODIOXAN-2-CARBOXYLATES USING ESTERASE FROM SERRATIA MARCESCENS | SEPRACHEM, INC. (US) | 1996-12-19 | — | — | WO | claimed |
| US-5529929-A | USING AQUEOUS SOLUTION OF MICROBIAL ESTERASE | SEPRACHEM, INC. (US) | 1996-06-25 | — | — | US | claimed |
| EP-3704090-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-05-27 | — | — | EP | disclosed |
| US-5529929-A | USING AQUEOUS SOLUTION OF MICROBIAL ESTERASE | SEPRACHEM, INC. (US) | 1996-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999741-B2 | Process for the synthesis of 6-((3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl)-3-(tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one | CDK8, PRMT8, RPS8 | HPGD 2516/4885ALDH1A1 2636/4885SMN1; SMN2 1150/4885 |
| US-20230122169-A1 | NOVEL METHOD FOR PREPARING (-)-CIBENZOLINE SUCCINATE | SDHA, SDHB, ALDH5A1 | HPGD 256/4885ALDH1A1 230/4885SMN1; SMN2 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.