Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 4/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 9/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608971 | 0.86 | PKM (0.46) | BRD4HTR6HTR2AHTR2CDRD3 | |
| SCHEMBL3913022 | 0.84 | BRD4 (0.51) | BRD4HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL5608331 | 0.82 | GSPT1 (0.48) | BRD4HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL1801399 | 0.81 | TP53 (0.44) | HTR6LMNAMAPTTP53THRB | |
| SCHEMBL1819904 | 0.80 | BRD4 (0.52) | BRD4HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL5608793 | 0.78 | PKM (0.41) | BRD4HTR6HTR1AHTR1DHTR1B | |
| SCHEMBL3915082 | 0.71 | PTGDR2 (0.47) | HTR6HTR2AHTR2CDRD3PKM | |
| SCHEMBL1819641 | 0.69 | PGR (0.57) | BRD4PGRDDB1CRBNPKM | |
| SCHEMBL1804773 | 0.69 | MEN1 (0.46) | BRD4HTR6HTR2AHTR2CDRD3 | |
| SCHEMBL5610031 | 0.69 | BRD4 (0.54) | BRD4HTR6PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |