Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 6/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1801399 | 0.87 | TP53 (0.44) | LMNAHTR6MAPTTHRB | |
| SCHEMBL5608726 | 0.86 | BRD4 (0.53) | PKMKMT2AALDH1A1LMNAHTR6 | |
| SCHEMBL3915082 | 0.85 | PTGDR2 (0.47) | PKMPTGDR2MEN1KMT2AALDH1A1 | |
| SCHEMBL1804773 | 0.83 | MEN1 (0.46) | PKMPTGDR2MEN1KMT2AALDH1A1 | |
| SCHEMBL5617634 | 0.82 | MEN1 (0.49) | PKMPTGDR2MEN1KMT2AALDH1A1 | |
| SCHEMBL5608793 | 0.79 | PKM (0.41) | PKMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5608331 | 0.78 | GSPT1 (0.48) | PKMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL1819904 | 0.73 | BRD4 (0.52) | PKMLMNAHTR6MAPTHTR2A | |
| SCHEMBL1820048 | 0.73 | ERAP1 (0.46) | PKMLMNAMAPTTHRBHTT | |
| SCHEMBL3908576 | 0.72 | PTPN2 (0.42) | PKMPTGDR2LMNAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |