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SCHEMBL560874

SCHEMBL560874

CCOC(=O)c1ccc(C)n(-c2cccc(C(F)(F)F)c2)c1=O

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ELANE P08246 3/20 0.57
▸ CYP1A2 P05177 2/20 0.53
▸ NPSR1 Q6W5P4 2/20 0.53
▸ CYP2C9 P11712 2/20 0.53
▸ CYP2C19 P33261 1/20 0.53
▸ NOTUM Q6P988 1/20 0.52
▸ MAPT P10636 2/20 0.51
▸ APP P05067 1/20 0.51
▸ ADORA1 P30542 1/20 0.51
▸ GSR P00390 1/20 0.49
▸ ALDH1A1 P00352 2/20 0.49
▸ MRGPRX4 Q96LA9 1/20 0.47
▸ HPGD P15428 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ TP53 P04637 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4157201 0.84 CYP1A2 (0.52) ELANECYP1A2NPSR1CYP2C9CYP2C19
SCHEMBL561046 0.84 NOTUM (0.68) ELANECYP1A2NOTUMMAPTGSR
SCHEMBL561882 0.83 CYP1A2 (0.51) ELANECYP1A2NPSR1CYP2C9CYP2C19
SCHEMBL5758541 0.83 ELANE (0.59) ELANECYP1A2NOTUMMAPTGSR
SCHEMBL5757200 0.81 ELANE (0.60) ELANECYP1A2NPSR1CYP2C9CYP2C19
SCHEMBL3061680 0.81 ALDH1A1 (0.57) MAPTALDH1A1HPGDHTTTP53
SCHEMBL4157069 0.81 CYP1A2 (0.48) ELANECYP1A2NPSR1CYP2C9CYP2C19
SCHEMBL5758934 0.81 CYP2C9 (0.48) ELANECYP1A2NPSR1CYP2C9CYP2C19
SCHEMBL4021797 0.81 NOTUM (0.49) ELANECYP1A2NPSR1CYP2C9CYP2C19
SCHEMBL5759279 0.81 CYP2C9 (0.51) ELANECYP1A2NPSR1CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1663973-B3 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE ASTRAZENECA AB (SE) 2019-09-25 — — EP disclosed
EP-1663973-B1 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE ASTRAZENECA AB (SE) 2013-12-25 — — EP disclosed
US-8501784-B2 2-pyridone derivatives as neutrophil elastase inhibitors and their use ASTRAZENECA AB (SE) 2013-08-06 — — US disclosed
US-20120269872-A1 NOVEL SALT 628 ASTRAZENECA AB (SE) 2012-10-25 — — US disclosed
US-20120269872-A1 NOVEL SALT 628 ASTRAZENECA AB (SE) 2012-10-25 — — US disclosed
US-8232296-B2 Salt 628 ASTRAZENECA AB (SE) 2012-07-31 — — US disclosed
US-8232296-B2 Salt 628 ASTRAZENECA AB (SE) 2012-07-31 — — US disclosed
US-20120035157-A1 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE ASTRAZENECA AB (SE) 2012-02-09 — — US disclosed
US-8063073-B2 2-pyridone derivatives as neutrophil elastase inhibitors and their use ASTRAZENECA AB (SE) 2011-11-22 — — US disclosed
WO-2010094964-A1 TOSYLATE SALT OF A 5-PYRAZOLYL-2-PYRIDONE DERIVATIVE, USEFUL IN THE TREATMENT OF COPD ASTRAZENECA AB (SE) 2010-08-26 — — WO disclosed
EP-1861370-A1 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE AstraZeneca AB (SE) 2007-12-05 — — EP disclosed
US-20070203129-A1 2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use ASTRAZENECA AB (SE) 2007-08-30 — — US disclosed
US-20070043036-A1 2-Pyridone derivatives as neutrophil elastase inhibitors and their use ASTRAZENECA AB (SE) 2007-02-22 — — US disclosed
CN-1856467-A 2-pyridone derivatives as inhibitors of neutrophil elastase and uses thereof ASTRAZENECA AB (SE) 2006-11-01 — — CN disclosed
WO-2006098683-A1 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE ASTRAZENECA AB (SE) 2006-09-21 — — WO disclosed
EP-1663973-A1 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE AstraZeneca AB (SE) 2006-06-07 — — EP disclosed
EP-1562902-B1 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE ASTRAZENECA AB (SE) 2006-05-03 — — EP disclosed
US-20060035938-A1 2-Pyridone derivatives as inhibitors of neutrophile elastase ASRAZENECA AB (SE) 2006-02-16 — — US disclosed
CN-1711243-A 2-pyridone derivatives as inhibitors of neutrophil elastase ASTRAZENECA AB (SE) 2005-12-21 — — CN disclosed
WO-2005026123-A1 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE ASTRAZENECA AB (SE) 2005-03-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035157-A1 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE SERPINB1, ELANE, SERPINE1 ELANE 2/4885CYP1A2 330/4885NPSR1 1537/4885
US-20070203129-A1 2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use SERPINB1, ELANE, SERPINE1 ELANE 2/4885CYP1A2 309/4885NPSR1 1584/4885
US-20120269872-A1 NOVEL SALT 628 REN, SCN8A, SLC38A7 ELANE 1755/4885CYP1A2 2967/4885NPSR1 2781/4885
US-20060035938-A1 2-Pyridone derivatives as inhibitors of neutrophile elastase SERPINB1, ELANE, SERPINE1 ELANE 2/4885CYP1A2 388/4885NPSR1 1225/4885
US-20070043036-A1 2-Pyridone derivatives as neutrophil elastase inhibitors and their use SERPINB1, ELANE, SERPINE1 ELANE 2/4885CYP1A2 309/4885NPSR1 1584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.