Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GHSR | Q92847 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5611456 | 0.85 | THRB (0.61) | POLBTHRBTP53CYP1A2CYP2D6 | |
| SCHEMBL5611548 | 0.85 | TP53 (0.61) | POLBTHRBTP53CYP1A2CYP2D6 | |
| SCHEMBL5611981 | 0.83 | ADORA3 (0.41) | POLBTP53KDM4EALDH1A1LMNA | |
| SCHEMBL1688907 | 0.83 | GRM1 (0.44) | KDM4EKMT2AADORA3GRM1 | |
| SCHEMBL1689073 | 0.82 | TP53 (0.51) | POLBTHRBTP53CYP1A2CYP2D6 | |
| SCHEMBL1688973 | 0.80 | KDM4E (0.46) | CYP1A2CYP2D6CYP2C9CYP2C19KDM4E | |
| SCHEMBL5611629 | 0.78 | SMN1; SMN2 (0.41) | TP53CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5612509 | 0.77 | MAPT (0.62) | POLBTHRBTP53SMN1; SMN2KDM4E | |
| SCHEMBL5611689 | 0.77 | KDM4E (0.43) | POLBTP53KDM4EALDH1A1LMNA | |
| SCHEMBL1688982 | 0.77 | KDM4E (0.43) | KDM4EADORA3GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807429-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM, LLC (BM) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006047516-A2 | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY | IRM LLC (BM) | 2006-05-04 | — | — | WO | disclosed |