Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.37 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | DCUN1D2 | Q6PH85 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31231553 | 1.00 | AKT1 (0.41) | AKT1AKT2DCUN1D1NISCHSMARCA2 | |
| SCHEMBL2197897 | 0.89 | ALDH1A1 (0.38) | AKT1AKT2PBRM1ALDH1A1MAPK1 | |
| SCHEMBL415 | 0.85 | NPC1 (0.40) | ALDH1A1MAPK1HPGDNPC1RAB9A | |
| SCHEMBL16735645 | 0.85 | ABL1 (0.47) | ALDH1A1HSD17B10HPGDBCL2L1NPC1 | |
| SCHEMBL9868 | 0.83 | AKT1 (0.46) | AKT1AKT2SMARCA2SMARCA4PBRM1 | |
| SCHEMBL28531472 | 0.81 | AKT1 (0.45) | AKT1AKT2SMARCA2SMARCA4PBRM1 | |
| SCHEMBL6741233 | 0.81 | AKT1 (0.45) | AKT1AKT2SMARCA2SMARCA4PBRM1 | |
| SCHEMBL8020144 | 0.80 | ALDH1A1 (0.44) | AKT1AKT2NISCHALDH1A1HSD17B10 | |
| SCHEMBL12989702 | 0.79 | AKT1 (0.48) | AKT1AKT2ALDH1A1HSD17B10MAPK1 | |
| SCHEMBL17443257 | 0.79 | PTGS2 (0.43) | AKT1AKT2ALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004116-A1 | 1H-1,2,3-triazol-4-yl derivatives; antiangiogenesis agents | SMITHKLINE BEECHAM CORPORATION | 2005-01-06 | — | — | US | claimed |
| US-20030220371-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2003-11-27 | — | — | US | claimed |
| EP-1274424-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | claimed |
| EP-1274424-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-15 | — | — | EP | claimed |
| WO-2001078723-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-25 | — | — | WO | claimed |
| EP-0310083-B1 | PROCESS FOR QUENCHING OR SUPPRESSING THE FLUORESCENCE OF OPTICALLY BRIGHTENED SUBSTRATES | CIBA-GEIGY AG (CH) | 1993-01-13 | — | — | EP | claimed |
| EP-0259530-B1 | METHOD FOR PREPARING 2-PHENYLBENZOTRIAZOLES AND 2-PHENYLBENZOTRIAZOLE-N-OXIDES | CHEMIPRO KASEI KAISHA LTD (JP) | 1992-04-08 | — | — | EP | claimed |
| US-4950304-A | AFTERTREATMENT OR PRETREATMENT OF NYLON TRICOT FABRICS WITH A UV ABSORBER AND FIXING | CIBA-GEIGY CORPORATION (US) | 1990-08-21 | — | — | US | claimed |
| EP-0310083-A1 | Process for quenching or suppressing the fluorescence of optically brightened substrates | CIBA-GEIGY AG (CH) | 1989-04-05 | — | — | EP | claimed |
| US-20070077641-A1 | Methionine aminopeptidase and methods of use | PALMER LESLIE | 2007-04-05 | — | — | US | disclosed |
| EP-1624849-A2 | METHIONINE AMINOPEPTIDASE AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005016237-A2 | METHIONINE AMINOPEPTIDASE AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20050004116-A1 | 1H-1,2,3-triazol-4-yl derivatives; antiangiogenesis agents | SMITHKLINE BEECHAM CORPORATION | 2005-01-06 | — | — | US | disclosed |
| US-20030220371-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2003-11-27 | — | — | US | disclosed |
| EP-1274424-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | disclosed |
| EP-1274424-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001078723-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004116-A1 | 1H-1,2,3-triazol-4-yl derivatives; antiangiogenesis agents | METAP1, METAP2, DNPEP | AKT1 1984/4885AKT2 1401/4885DCUN1D1 3013/4885 |
| US-20030220371-A1 | Compounds and methods | METAP2, METAP1, DNPEP | AKT1 2374/4885AKT2 1089/4885DCUN1D1 3957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.