SCHEMBL5612971

SCHEMBL5612971

Nc1ncnc2[nH]c(=O)cnc12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.53
ALDH1A1 P00352 2/20 0.53
HSD17B10 Q99714 2/20 0.53
LMNA P02545 2/20 0.53
GLA P06280 1/20 0.53
PMP22 Q01453 1/20 0.53
PI4KA P42356 4/20 0.38
PI4K2B Q8TCG2 4/20 0.38
PI4K2A Q9BTU6 4/20 0.38
PI4KB Q9UBF8 4/20 0.38
LRRK2 Q5S007 3/20 0.38
XDH P47989 2/20 0.38
RET P07949 2/20 0.38
ERAP1 Q9NZ08 1/20 0.38
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
RPS6KA3 P51812 2/20 0.37
MAPKAPK2 P49137 1/20 0.37
CSNK2A1 P68400 1/20 0.37
PLK3 Q9H4B4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5481545 0.71 KDM4E (0.51) KDM4EALDH1A1HSD17B10LMNAGLA
Isoxanthopterin SCHEMBL9148336 0.69 KDM4E (1.00) KDM4EALDH1A1HSD17B10LMNAGLA
SCHEMBL8725013 0.69 ALDH1A1 (0.49) KDM4EALDH1A1HSD17B10LMNAGLA
SCHEMBL42313 0.68 ADORA2A (0.42) KDM4EALDH1A1HSD17B10LMNAGLA
SCHEMBL5612938 0.68 NSD2 (0.39) KDM4EALDH1A1HSD17B10LMNAGLA
SCHEMBL23326745 0.68 ENPP1 (0.44) PI4KAPI4K2BPI4K2API4KBLRRK2
SCHEMBL6379644 0.68 ALDH1A1 (0.53) KDM4EALDH1A1HSD17B10LMNAGLA
Adenine SCHEMBL8110 0.66 PI4KA (0.48) LMNAPI4KAPI4K2BPI4K2API4KB
Adenine SCHEMBL3414603 0.66 PI4KA (0.48) LMNAPI4KAPI4K2BPI4K2API4KB
Adenine SCHEMBL3416954 0.66 PI4KA (0.48) LMNAPI4KAPI4K2BPI4K2API4KB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070238096-A1 Hybrid energy transfer for nucleic acid detection THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2007-10-11 US claimed
WO-2007103558-A2 HYBRID ENERGY TRANSFER FOR NUCLEIC ACID DETECTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-09-13 WO claimed
US-20070238096-A1 Hybrid energy transfer for nucleic acid detection THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2007-10-11 US disclosed
WO-2007103558-A2 HYBRID ENERGY TRANSFER FOR NUCLEIC ACID DETECTION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2007-09-13 WO disclosed
EP-1259512-B1 PTERIDINE COMPOUNDS FOR THE TREATMENT OF PSORIASIS ASTRAZENECA AB (SE) 2003-09-24 EP disclosed