Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 8/20 | 0.54 |
| ▸ | TUBB | P07437 | 8/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 8/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 8/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 8/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 8/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 8/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 8/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 8/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 8/20 | 0.54 |
| ▸ | TUBA1A | Q71U36 | 8/20 | 0.54 |
| ▸ | TUBA1C | Q9BQE3 | 8/20 | 0.54 |
| ▸ | TUBB6 | Q9BUF5 | 8/20 | 0.54 |
| ▸ | TUBB2B | Q9BVA1 | 8/20 | 0.54 |
| ▸ | TUBB1 | Q9H4B7 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL561427 | 1.00 | ADORA2B (0.55) | ADORA2BTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29112159 | 0.76 | KDM4E (0.55) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL7450026 | 0.73 | KMT2A (0.52) | TUBB1ALDH1A1KMT2AMEN1PKM | |
| SCHEMBL7450036 | 0.73 | KMT2A (0.52) | TUBB1ALDH1A1KMT2AMEN1PKM | |
| SCHEMBL7402271 | 0.72 | MAPT (0.48) | ADORA2BRAB9AKDM4EALDH1A1LMNA | |
| SCHEMBL378879 | 0.71 | ADORA2B (1.00) | ADORA2BALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1508832 | 0.70 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL1508835 | 0.70 | TUBB4A (1.00) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL789316 | 0.69 | NPC1 (0.50) | NPC1RAB9AKDM4EALDH1A1KMT2A | |
| SCHEMBL789315 | 0.69 | NPC1 (0.50) | NPC1RAB9AKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9868705-B2 | Tetra-aryl cyclobutane inhibitors of androgen receptor action for the treatment of hormone refractory cancer | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160229811-A1 | TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER | DUKE UNIVERSITY | 2016-08-11 | — | — | US | disclosed |
| WO-2015048246-A1 | TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2015-04-02 | — | — | WO | disclosed |
| EP-2097415-B1 | 8-ETHINYLXANTHINE DERIVATIVES AS SELECTIVE A2A RECEPTOR ANTAGONISTS | UNIV BONN (DE) | 2014-10-29 | — | — | EP | disclosed |
| US-20120309774-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADENOSINE THERAPEUTICS, LLC | 2012-12-06 | — | — | US | disclosed |
| US-8153781-B2 | Dendrimer conjugates of agonists and antagonists of the GPCR superfamily | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-04-10 | — | — | US | disclosed |
| US-20120035192-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADENOSINE THERAPEUTICS, LLC | 2012-02-09 | — | — | US | disclosed |
| US-8044061-B2 | Parkinson's disease, catalepsy, dystonia, dyskinetic syndrome, restless legs syndrome, migraine, pain, dementia, neurodegenerative disorders, alcohol withdrawal and/or ischemic conditions such as e.g. stroke or cardiac ischemia. | UCB PHARMA GMBH (DE) | 2011-10-25 | — | — | US | disclosed |
| US-7985754-B2 | Selective antagonists of A2A adenosine receptors | TROVIS PHARMACEUTICALS, LLC (US) | 2011-07-26 | — | — | US | disclosed |
| EP-2170401-A1 | DENDRIMER CONJUGATES OF AGONISTS AND ANTAGONISTS OF THE GPCR SUPERFAMILY | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-1019427-A1 | N?6 -SUBSTITUTED-ADENOSINE-5'-URONAMIDES AS ADENOSINE RECEPTOR MODULATORS | Medco Research, Inc. (US) | 2000-07-19 | — | — | EP | disclosed |
| EP-0991414-A1 | METHODS AND COMPOSITIONS FOR REDUCING ISCHEMIC INJURY OF THE HEART BY ADMINISTERING ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2000-04-12 | — | — | EP | disclosed |
| US-6048865-A | NERVOUS SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS; BRAINDISORDERS | MEDCO RESEARCH, INC. (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1999020284-A1 | METHODS FOR REDUCING ISCHEMIC INJURY OF THE HEART VIA THE SEQUENTIAL ADMINISTRATION OF MONOPHOSPHORYL LIPID A AND ADENOSINE RECEPTOR AGENTS | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-04-29 | — | — | WO | disclosed |
| WO-1999006053-A1 | N6-SUBSTITUTED-ADENOSINE-5'-URONAMIDES AS ADENOSINE RECEPTOR MODULATORS | MEDCO RESEARCH, INC. (US) | 1999-02-11 | — | — | WO | disclosed |
| US-5861405-A | A2-SELECTIVE ADENOSINE RECEPTOR ANTAGONIST AS ANTIDEPRESSANTS AND CNS STIMULANTS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1999-01-19 | — | — | US | disclosed |
| US-5859019-A | Methods for protecting against cardiac ischemia by administering adenosine A2a receptor antagonists | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1999-01-12 | — | — | US | disclosed |
| WO-1998050047-A1 | METHODS AND COMPOSITIONS FOR REDUCING ISCHEMIC INJURY OF THE HEART BY ADMINISTERING ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1998-11-12 | — | — | WO | disclosed |
| WO-1998039008-A1 | METHODS AND COMPOSITIONS FOR PROTECTING AGAINST CARDIAC ISCHEMIA BY ADMINISTERING ADENOSINE A2A RECEPTOR ANTAGONISTS | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1998-09-11 | — | — | WO | disclosed |
| WO-1994025462-A1 | 8-SUBSTITUTED 1,3,7-TRIALKYL-XANTHINE DERIVATIVES AS A2-SELECTIVE ADENOSINE RECEPTOR ANTAGONISTS | THE UNITED STATES OF AMERICA, REPRESENTED BY THE (US) | 1994-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229811-A1 | TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER | AR, FSHR, ESRRB | ADORA2B 2230/4885TUBB4A 1609/4885TUBB 676/4885 |
| US-20120309774-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADORA2A, ADORA3, ADORA2B | ADORA2B 3/4885TUBB4A 3429/4885TUBB 3707/4885 |
| US-20120035192-A1 | SELECTIVE ANTAGONISTS OF A2A ADENOSINE RECEPTORS | ADORA2A, ADORA3, ADORA2B | ADORA2B 3/4885TUBB4A 3429/4885TUBB 3707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.