Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | MMP10 | P09238 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616141 | 0.93 | RAB9A (0.56) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL8358827 | 0.89 | RAB9A (0.61) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL4718358 | 0.89 | RAB9A (0.59) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL5615905 | 0.88 | RAB9A (0.58) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL5615645 | 0.86 | RAB9A (0.59) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL4717221 | 0.86 | RAB9A (0.59) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL5615885 | 0.85 | RAB9A (0.54) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL14602325 | 0.85 | RAB9A (0.56) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL4718511 | 0.85 | RAB9A (0.59) | RAB9AEGLN1NPC1POLBCHRM4 | |
| SCHEMBL5615861 | 0.85 | RAB9A (0.58) | RAB9AEGLN1NPC1POLBCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166609-B2 | Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20040167120-A1 | Novel Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167120-A1 | Novel Pyrimidine-4,6-dicarboxylic acid diamides for selectively inhibiting collagenases | MMP13, DPYD, MMP1 | RAB9A 3108/4885EGLN1 1003/4885NPC1 4376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.